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Furthermore, SFN may activate Nrf2 by initiating the transcription of trigger receptor expressed on myeloid cells-2 (TREM2) in the medial PFC (mPFC), increasing the expression of the M2 microglial marker arginase 1 (ARG1), which may alleviate depressive phenotypes through its anti-inflammatory and neuroprotective functions (He et al., 2022)

Carotenoid concentrations in your skin plummet, stripping away natural protection against oxidative damage

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10.3389/neuro.07.003.2009 76 FlemingS

For immune-focused analysis, we manually selected pathways from Gene Ontology (GO) Biological Processes, KEGG, BioCarta, WikiPathways, Reactome, and Hallmarks MsigDB collections, grouping them into three categories: cytokine, antigen processing/presentation and other immune-related