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doi: 10.1124/jpet.103.052225

Angiopoietin 1 maintains the endothelial cell quiescent, by taking its places Angiopoietin 2 trigger endothelial proliferation

there are a number of causes for very similar symptoms

Neuropsychiatric disorders: predominance of astrocytic atrophy and loss of function Mood disorders Major depressive disorder (MDD) Decreases in the total number of glial cells and astrocytes are the main and most consistent histopathological hallmark of MDD post-mortem brains