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Acta 1827 , 401410 (2013)

*Correspondence: Ken Takahashi [email protected] This article was submitted to Cardiovascular Metabolism, a section of the journal Frontiers in Cardiovascular Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

During cellular stress, such as nutrient starvation and catabolic stress after trauma, surgery, infection, sepsis, or cancer cachexia, blood glutamine levels are severely decreased 144

In gastrointestinal stromal tumors, cotreatment of imatinib and autophagy inhibitors (like chloroquine) cause apoptosis [356, 357].The endoplasmic reticulum (ER) is an essential subcellular structure that maintains cellular homeostasis and can be disrupted by a variety of pathological conditions like cancer, resulting in induction of ER stress which if remains sustained can either kill cancer cells by induction of apoptosis and ferroptosis or help them to grow, survive and induce drug resistance if moderately activated [358]