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Very sophisticated studies, including microsatellite and high-density SNP genotypes, combined with the whole genome sequence data of a large Old Order Amish pedigree sample, failed to identify a particular set of gene loci, which would identify at-risk individuals (71)

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Instead, it supports muscle growth indirectly by accelerating tissue recovery, reducing chronic inflammation, strengthening tendons and ligaments, and improving gut health for better nutrient absorption

Some concerns have been raised as to the potential detrimental effect of vitamin E supplementation on cancer-related outcomes