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The curcumin analog ALZ003 increased the production of ROS and ubiquitinated the androgen receptor resulting in its degradation, which potentiated TMZ resistance

Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day

This is largely due to the difficulty of distinguishing cell identity feature sets from cell-state markers in transcriptomic data, with classical correlation analyses relying heavily on statistical differences to segregate cell identities

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