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More generally, in the discussion that follows, we summarize and respond to public comments we received on the remaining proposals and considerations described in section III.G.7.c.(2) of the CY 2025 PFS proposed rule

Vitamin B12 for hair, skin, and nails If you have a very low level of B12, you may be prone to hyperpigmentation (dark spots) on your skin, vitiligo (light patches on your skin), mouth ulcers, eczema, and acne

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Individual response varies significantly based on body weight, metabolic factors, and the specific condition being addressed