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NIH ODS Fact Sheet for Health Professionals: Vitamin B12 (updated 2024)

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While these regulatory mechanisms are well established in maintaining basal iron metabolism, the dynamic changes and temporal regulation of HERC2 and FBXL5 during different phases of ischemic injury, particularly in distinguishing between acute ischemia and reperfusion periods, remain poorly understood and represent an important area for future investigation to fully elucidate the complex regulation of iron metabolism throughout the progression of ischemic injury

M., Gass J