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doi:10.1007/s11095-013-1007-6 [PMC Full Text] [PubMed] [Crosslink] McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H

Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, et al

A previous study have identified a potential therapeutic strategy for LC, demonstrating that N-desmethyl imipramine hydrochloride modulate RBMS1 levels in IR-resistant LC cells, thereby enhancing their susceptibility to radiation therapy (119)

3.1 Glucose metabolism Lactate is a necessary byproduct of glycolysis, and tumor cells in the TIME are extremely dependent on glycolytic capacity, excreting large amounts of lactate, resulting in a localized low glucose, low oxygen, and acidic environment