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(2005, 2010) found increased CSF levels of the endogenous cannabinoid anandamide in untreated PD patients, which were unrelated to the severity of the disease (Pisani et al., 2005) and reversed by chronic dopaminergic replacement (Pisani et al., 2010)

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Circadian Rhythm Studies The peptide is commonly examined in laboratory models involving biological timing systems and sleep-wake regulation pathways