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Tobacco Addiction: Symptoms, Causes, Effects and Treatment How Big Tobacco made cigarettes more addictive Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention Nature Reviews Cancer Tobacco Addiction: Nicotine and Other Factors, Animation
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