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Clinical monitoring and patient safety advice includes: Gastrointestinal symptoms : Patients should report severe or persistent nausea, vomiting, or abdominal pain, which may indicate pancreatitis (a warning in tirzepatide labeling) or require dose adjustment

Instead, focusing on cooking methods using a lower temperature such as steaming, baking, and stir-frying to help reduce the chances of AGEs being formed

The currently available drugs for the treatment of these diseases often have significant adverse effects, particularly those used in long courses of treatment, ranging from relatively mild (such as nausea or loss of appetite) to severe (such as nephrotoxicity or peripheral neuropathy) (183186)