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Interestingly, certain MPs may be metabolically processed by the human gut microbiota without causing detrimental alterations

The activation of the PI3K/Akt pathway can also promote an increase in HIF-1 level, which upregulates VEGF expression, and VEGF then activates the PI3K/Akt pathway through the VEGFR2 receptor on the cell membrane, thus amplifying the protective effect on neurovascular units (Karar and Maity, 2011

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doi: 10.3390/ijms141021021, 8 ArakawaM.ItoY

Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons