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However, drug resistance is still a problem during fludarabine treatment [11]

Another major question that remains unanswered as yet is that whether switching the normal machinery from eumelanin (which is protective against UV radiation) to pheomelanin (which photosensitizes UV-induced deoxyribonucleic acid damage as observed in cultured human melanocytes) by an external agent for long duration would result in an increased incidence of skin cancers