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However, beyond masking the allogeneic properties of the sperm cell, the accompanying increase in electronegativity brought about by sialyation has formed the basis of electrophoretic separation techniques designed to rapidly fractionate mature spermatozoa away from other deleterious ejaculate contaminates (i.e., immature germ cells, bacteria, and leucocytes) (90) ( Figure 1 )

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More recently, to target the vasculogenic mimicry (induced by hypoxia and rapidly invading tumor cells) by platelet mimetic pH/redox sensitive nanogels co-loaded with doxorubicin (120 nm size, 16 mV zeta potential) were developed by Li and co-workers