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In total, ~150 biochemical derivatives with metabolic activity have been described, among which tetrahydrofolates are the most relevant due to their roles in DNA and RNA synthesis, cell division, methylation reactions and as cofactors in multiple metabolic pathways (30,36)

2 Fernandez-Checa J, Lu SC, Ookhtens M, DeLeve L, Runnegar M, Yoshida H, Saiki H, Kannan R, Garcia-Ruiz C, Kuhlenkamp JF, Kaplowitz N: The regulation of hepatic glutathione

Regenerative signalling brings underlying issues closer to the surface

E., Flickinger, M

This chemotaxis allows tumor cells to move directionally through brain tissue, often toward vascularized areas, facilitating invasion (82)