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Indeed, using a concentration of CSE that does not induce overt endothelial cell death, we show here that acute exposure of monolayers of normoxic cerebral endothelial cells to CSE markedly increased paracellular permeability, indicative of BBB disruption

This decline appears to be slower for younger women than other groups 3 , and importantly, women who smoke do not necessarily quit if they become pregnant 4,5