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doi:10.1007/s11356-016-6823-x Ethics declarations Conflict of interest The authors declare that they have no conflict of interests

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STAT3 and CREB coordinate the hyperaminoacidemia-induced VGF upregulation To elucidate the mechanism of glutamine and alanine-induced VGF upregulation in cells, we used the databases including AnimalTFDB 26 , GTRD 27 , and TFBIND 28 to predict the transcription factors that could bind to the VGF promoter