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(2012) found that in extreme obesity scenarios such as high-fat diet-fed mice, HIF1 is accumulated in white adipose tissue, leading to a reduced adipocyte mitochondrial content, which compromised fat oxidation and favored adipocyte intracellular lipid accumulation and obesity

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Tang TT, Wang B, Wu M et al (2020) Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI