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Results of several phase 3 clinical trials demonstrated that additional treatment of diabetic subjects with SGLT2i leads to a significant reduction in cardiovascular endpoints, including the classical major adverse cardiovascular event (MACE) endpoint (non-fatal myocardial infarction, non-fatal stroke, cardiovascular death), all-cause mortality, and/or in particular, hospitalization for HF [138139140]

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Liver toxicity ranges from asymptomatic mild elevation of transaminases with spontaneous resolution to liver failure and death.Current best practice involves maintaining a high level of clinical suspicion and conducting thorough hepatological investigations, guided by the international RUCAM criteria, a diagnostic algorithm for DILI