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Pawankar et al., 2011

The high sensitivity (100% for the known carcinogenic and mutagenic NAs tested here) of HepG2 cells supplemented with hamster S9-mix, as compared to PHH and PRH, in principle might make this system a valuable tool for hazard identification and potential follow up of negative/borderline EAT test results to provide further reassurance for the EAT result

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Interestingly, stem cell transplantation in the past decade was an attractive clinical therapeutic option in CML patients, but it is not successful due to independently more death rates in older patients

Non-alcoholic steatohepatitis (NASH) , characterised by inflammation and hepatocyte injury, or advanced fibrosis and cirrhosis can disrupt normal liver function