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242 Krabbe disease is a fatal pediatric neurodegenerative LSD caused by insufficient activity of the enzyme galactosylceramidase (GALC), which degrades galactosylceramide (a major component of myelin sheaths) and other terminal -galactosecontaining sphingolipids

10.1186/s12868-017-0361-4 65 Reyes-MontaoE

J Immunol 185(1):605614 Ryu C, Sun H, Gulati M, Herazo-Maya JD, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J (2017) Extracellular mitochondrial DNA is generated by fibroblasts and predicts death in idiopathic pulmonary fibrosis

These conducive effects include the refrain of LDL retention and aggregation, the interference of oxidative stress-related signaling pathways, the inhibiton of ECs and macrophages activation, the modulation of SMCs migration and proliferation and the facilitation of RCT in macrophage cells, which can subsequently reduce foam cells formation and dramatically reverse the progression of atherosclerosis 7,21-25

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