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doi: 10.1038/s41590-020-00816-x 5 AkramMDaniyalMSultanaSOwaisAAkhtarNZahidRet al

PROs measures were not different regarding gender, disease activity during study time, presence of intrathecal synthesis of immunoglobulin M (IgM oligoclonal bands), need of treatment escalation, or season of the year at time of completion of the questionnaire

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Without adequate blood flow, tissues simply can't get the oxygen and nutrients they need to repair themselves