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This increases GI side effects without proportionally increasing weight loss

In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence

Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues

Many people experience low B12 levels due to factors such as dietary restrictions, digestive issues, or certain health conditions

Those who have had bariatric surgery or have malabsorption issues might need special dosing plans