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KG exerts a significant impact on the activation of macrophages: it promotes M2 macrophage polarization via JMJD3-dependent epigenetic reprogramming while suppressing M1 proinflammatory responses by inhibiting NF-B through PHD-mediated IKK hydroxylation (262)

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Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E-2 production