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Cell 126 , 677689 (2006)

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Abnormal or faulty mechanotransduction may lead to a range of diseases, such as deafness (Lee et al., 2023), cardiovascular disease (Lyon et al., 2015), metabolic defects (Romani et al., 2021), fibrosis (Ostrow and Sachs, 2005), and osteoporosis ( Mechanical signal transduction involves the direct stimulation of mechanically activated (MA) ion channels by mechanical forces applied to the cell membrane, which convert mechanical forces into biochemical signals and thus respond rapidly and efficiently to the excitation of the cell membrane or the activation of intracellular signals (Qin et al., 2021)