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Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment Consent to Participate/Publish All participants provided written, informed consent

The peptide crosslinker, GKK C GPQG IWGQ C KKG was synthesized using standard solid-phase peptide synthesis on FMOC-Gly-Wang resin (EMD) on a Liberty 1 Microwave-Assisted Peptide Synthesizer (CEM) with UV monitoring, as previously described 4,5,37

Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy