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The level of stable adducts formed by E 1 (E 2 )-2,3-Q is still lower than the level of the depurinating adducts 2-OHE 1 (E 2 )-6-N3Ade [21, 26]

The underlying repair processes, including new blood vessel formation that studies have examined in animal models, are the plausible mechanism, though the human timeline is not precisely established