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We demonstrated that, at low doses (ng), local (intraplantar) or systemic (intraperitoneal) injections of thymulin resulted in hyperalgesia with an increase in proinflammatory mediators, and that this peptide could act directly on the afferent nerve terminals through prostaglandinE2 (PGE2)dependent mechanisms, thus forming a neuroimmune loop involving capsaicinsensitive primary afferent fibers

Neuropsychopharmacology 42 , 787800 (2017)

However, many trusted sources recommend aiming for around 2 liters of water daily for women and 3 liters daily for men an amount considered more than adequate by this study

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Using an inducible, epidermal-specific c-Jun/JunB double-knockout (DKO*) mouse model that faithfully recapitulates psoriatic skin and arthritis, the authors reveal profound metabolic alterations characterized by reductions in dermal fat and circulating free fatty acids, as well as elevated -hydroxybutyrate [3]