![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides](https://ars.els-cdn.com/content/image/1-s2.0-S0223523421002087-ga1.jpg)
interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides
Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect New mechanistic insights into halogen dependent cytotoxic pattern of monohaloacetamide disinfection byproducts ScienceDirect Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities
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![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides](https://pubs.acs.org/cms/10.1021/acs.jmedchem.3c00737/asset/images/medium/jm3c00737_0012.gif)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides](https://ars.els-cdn.com/content/image/1-s2.0-S0223523425008724-ga1.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides](https://ars.els-cdn.com/content/image/1-s2.0-S0304389423024160-ga1.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41556-026-01921-z/MediaObjects/41556_2026_1921_Fig1_HTML.png)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Expanding the Chemistry of Dihaloacetamides](https://www.mdpi.com/biomedicines/biomedicines-10-00891/article_deploy/html/images/biomedicines-10-00891-g005.png)