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Notably, the dithioacetate derivatives 22 and 24 with 20 L of the homogenized myocardial extract showed a higher antioxidant activity than without the extract, and surpassed that of the 5-SH metabolite at lower concentrations after 30 min of incubation, clearly demonstrating that the DPPH inhibitory activity of the dithioacetate derivatives in the presence of the extract continuously increases during the 30-min incubation time due to the sustained concurrent release of two antioxidant molecules: the 5-SH metabolite and H 2 S

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374 Exendin-4 has also been shown to stimulate osteoblast activity and mitigate bone loss in an ovariectomized mouse model

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