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Description

Pathog Dis (2016) 74(1):ftv096

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The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments

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The ability of an antibody or a T-cell, specific for one antigen, to react with a second antigen

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Conditional GPX4 knockout mice exemplify the risks of single-pathway targeting: while GPX4 deletion in PT cells protects against early AKI by eliminating damaged cells, long-term deletion activates the cGASSTING pathwaylikely via release of fragmented mitochondrial DNAleading to sustained type I interferon signaling and progressive interstitial fibrosis

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