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138,139,140 In turn, NF-B can induce TNF expression in the context of inflammation, such as lipopolysaccharide (LPS) stimulation

Recently, Lin and colleagues showed that vitamin E could reverse the effect of the cytotoxic drug bioallethrin on human glioblastoma cells by inhibiting OS and endorsing endogenous redox defense pathways, thus obstructing the chemotherapeutic effects of the drug [105]

The pathophysiology of IC/BPS is poorly understood, and theories include chronic inflammation, autoimmune dysregulation, bacterial cystitis, urothelial dysfunction, deficiency of the glycosaminoglycan (GAG) barrier and urine cytotoxicity

ROS scavengers like Nacetylcysteine and Methotrexate, which inhibit NET formation by reducing ROS formation, have shown remarkable therapy benefits in some clinical or preclinical trials (210, 211)

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