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Current evidence indicates that, across multiple models, 4-HNE activates inflammasomes, promotes calcium overload, impairs autophagylysosome flux, and interferes with transcriptional regulation and mRNA stability by modifying nuclear or RNA-binding proteins (Xiao Liang, 2024

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Tumor-induced stromal reprogramming drives lymph node transformation

Specifically, the FMD was shown to promote the infiltration of activated and cytotoxic immune cell populations, including total and activated intratumoral CD8 + T cells, M1-like macrophages, aDCs, and NK cells