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Interestingly, in the recently published systematic review by Lisa et al., men with gPRLomas had a better response to DA treatment compared to women PRL normalization was achieved in 55% and significant tumor shrinkage in 91% of men, whereas in 38% and 76% in women, respectively ( 6.10 Conclusions Although PRL-secreting PAs having a higher prevalence in women, those in males often pose challenges in clinical practice and have a multidirectional impact on male health