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Signs develop gradually and may include: Cardiac Manifestations: Reduced exercise tolerance Increased respiratory rate or effort Coughing, especially after activity Lethargy or fatigue Pale or slightly bluish gums during exercise In advanced cases, signs of congestive heart failure (laboured breathing, abdomen distension) Visual/Ocular Signs: Night blindness (initial symptom) Dilated pupils with reduced responsiveness Progressive vision loss Changes in eye shine or reflectivity Bumping into objects in dim light Hesitation on stairs or in new environments Additional Potential Signs: Poor coat quality Reproductive issues Delayed growth or development in puppies Increased susceptibility to infections Digestive disturbances Reduced muscle mass or tone The challenge with taurine deficiency is that clinical signs often appear only after significant depletion has occurred over months or years

Koochin, J

18, 477482 [Google Scholar] 32).Hans M., Keul H., Moeller M

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This tight polar anchoring stabilizes the complex (G = 7.37 0.47 kcal/mol), likely occluding the TCF/LEF binding interface and disrupting transcriptional co-activator recruitment