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Findings from animal models further support these observations, demonstrating that serum lactate levels are consistently elevated in monocrotaline-induced PH [57]

However, it has been observed that the c-Abl expression is downregulated in MMR deficient cells

Additionally, co-administration with bioenhancers like piperine could further boost its bioavailability and ensure greater therapeutic efficacy

Mice deficient in mdr1a and mdr1b revealed that P-gp knockout was not fatal in mice but likely increased the assimilation and neurotoxicity of various drugs ( mdr1a / mdr1b and mrp1 genes demonstrated that P-gp and MRP1 transporters were responsible for the development of resistance to anthracyclines, taxol, and vinca alkaloids (245)

37 EwersM.BiecheleG.Suarez-CalvetM.SacherC.BlumeT.Morenas-RodriguezE.et al (2020)