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Percutaneous procedures serve as an intermediate step between conservative therapy and decompression and surgical options (Masala et al., 2019)

On the other hand, accumulation of misfolded proteins per se was shown to directly inhibit the proteasome activity [78], exacerbating these toxic effects

Read source Yurko-Mauro, K., et al

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DBS targeting the ventral medial prefrontal cortex is thought to exert its antidepressant-like and cognitive enhancement effect by increasing expression of BDNF, Akt, and mammalian target of rapamycin (mTOR), and observed to restore stress-induced synaptic loss in the hippocampus (131)