glutamine increases glutathione Full article: Inhibition of metabolism sensitivity to plasma-activated medium-induced cytotoxicity Glutamine: Metabolism and Immune Function,

Under continuous oxidative stress, cellular organelles like mitochondria and the endoplasmic reticulum (ER) are damaged

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It is important to note that these findings are based exclusively on experimental observations and have not yet been confirmed in controlled clinical studies in humans

Interestingly, high GPX1 and GPX4 expression are correlated to poor prognosis in patients suffering AML, suggesting that targeting one or both proteins could be of high potential therapeutic value [36]

While RCTs minimize bias and provide strong causal inference, they are not always the most logical or practical choice