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doi: 10.1016/j.lfs.2021.119961 235 El-DesoukyMAFahmiAAAbdelkaderIYNasraldinKM

Availability of cystine/cysteine is the rate-limiting step in GSH synthesis counteracting ROS 18 , which prevents the execution of ferroptosis, an oxidative, non-apoptotic and iron-dependent form of regulated cell death caused by ROS-mediated lipid peroxidation 13,19,20

32 In contrast to GHD or populations defined by a medical disease, the ISS population is heterogeneous, including patients with familial short stature, CGD, partial or transient GH deficiency or resistance, and intrinsic short stature due to unidentified condition