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5.2.4 Novel pharmacotherapies and combination treatment As a multifactorial degenerative disease, OA often responds poorly to single-target therapies (9)

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Abdelnabi, R

Based on the position of selenocysteine within the polypeptide, selenoproteins can be categorized into two types: the first type, where selenocysteine is located at the N-terminus of the functional group, includes examples such as GPX, selenoprotein P, and selenoprotein W

Furthermore, curcumin-zinc oxide nanoparticles significantly increased GSH concentrations in the cerebral cortex, hippocampus, and striatum compared to curcumin alone, and more effectively reduced MDA levels (Fahmy et al., 2024)