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It involves a complex interaction of various cell types, cytokines, and inflammatory mediators

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S.RathP.ChauhanA.SakK.AggarwalD.ChoudharyR.et al (2022)

Distant metastasis and progression: Breast cancer metastasis is a complex, multicellular, and highly regulated process involving local invasion of primary tumor cells, epithelial-to-mesenchymal transition, invasion into the bloodstream, survival of tumor cells in the circulatory system, and colonization of secondary distant sites

However, emerging evidence highlights the role of EVs as active participants in glucose metabolism, influencing glucose uptake, glycolysis, the pentose phosphate pathway, and metabolic reprogramming [59, 60]