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just taking a sample of convenience and its unclear how participants were blinded to patch use in one case), were not registered on Clinicaltrials.gov, and were not published in what I consider rigorous journals that are listed on PubMed

Insulin and IGF-I appear to stimulate the secretion of klotho, whereas klotho inhibits insulin/IGF-I signaling and the activation of both hormone receptors

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Nevertheless, the macrophage membrane extraction process is complex and unfavorable for clinical translation