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An analysis of STAR*D showed that treatment with either tranylcypromine or extended-release venlafaxine plus mirtazapine yielded modest remission rates that were not statistically different between the 2 treatment groups.37 Although both treatment groups were similar in quality of response, the lower side effect profile, lack of dietary restrictions, and ease of use of venlafaxine and mirtazapine suggest that the combination may be preferred over the oral MAOI tranylcypromine for patients with treatment-resistant depression

The choice changes how much control there is over each compound's dose and schedule, and how much injection-site management is needed

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