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HOW INFLAMMATION LEADS TO DEPRESSION The evidence summarized in Table 2 highlights the established knowledge and recent evidence on how genetic predisposition and early life stress form a vulnerability for chronic immune dysregulation later in life, while acute infections, autoimmune disease and adverse lifestyle/metabolic factors act as triggers of sustained inflammation

The top ten specific and enriched CNAs identified from the METABRIC and TCGA datasets are underlined

showed that simvastatin develops T helper 2 cell polarization through up-regulation of the chitinase family member Ym1 in dendritic cells (DCs) [45]

RVX treatment at 7 mg/kg reduced BAX by 63.9% and NFB by 62.9%, while increasing BCL2 by 102.8% compared to the IR group

10.1016/j.jshs.2020.02.006 66 BrownB