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Pharmacol Res (2020) 160:105080

Introduction Adaptation to hypoxia is an extremely widespread event among living organisms, apparently being one of the most ancient evolutionary forms of adaptation (Bickler and Buck, 2007)

Its clinical significance in the neonate relates to its propensity for deposition in the skin and mucous membranes, producing easily identifiable jaundice (French jaune , yellow) or icterus (Greek ikteros )

Serum T3 measurements are of limited value due to the variability of T3 concentrations in blood after a T3 dose