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Afridi and Suk, 2023

Sleep disturbances: Difficulty falling or staying asleep is a reported side effect as Acamprosate impacts the neurotransmitters responsible for regulating sleep cycles

Blocking this receptor abolished the antidepressant effect of CBD, indicating that its effects are mediated by the serotonergic pathway and are associated with microRNA modulation in the vmPFC ( There is growing evidence that CBD is a promising candidate for the treatment of depression, acting through complex mechanisms that involve the modulation of multiple receptors, including CB1, CB2, G-protein-coupled receptor 55 (GPR55), 5-HT1A, and PPAR (Miao et al., 2025)