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This damage eventually leads to apoptosis and necrosis of the neurons (Nicklas et al., 1985

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However, they require triple quadrupole instruments to differentiate between molecules with the same mass or discern between analytes in a complicated mixture or a complex matrix

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Depending on the lab, some reference ranges may define homocysteine excess as greater than 10 or 11 mol/L, and levels under 4, 5, or even 6 mol/L may be considered too low