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Whether or not (and how) glutamine-glutamate metabolism of the different isoforms dictates the fate of the metabolites further down the TCA cycle needs further investigation, as well as the potential preferential role of GAC in glutamine dependency over KGA

By accentuating these advanced analytical methods, this review endeavors to provide a clear and in-depth insight into the latest technologies in carnitine analysis, addressing challenges posed by complex sample matrices and furnishing researchers with the most recent reference materials on carnitines in chromatographic and mass spectrometric detection