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Description

the combination index was less than 0.2 for all effective doses, with 19.8-fold and 5-fold shifts in the IC 50 (0.5 M for HG-3 and 0.38 M for MEC-1 cell line) ( Supplemental Table 3 , Supplemental Figure 8 )

46 Briefly, 50 L of plasma was added to 950 L of cold organic solvent MeOH/ACN (v/v, 1:1) and incubated at low temperature for a brief period (15 min) to enhance protein precipitation