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10.3390/biomedicines12040902 18 ChenX.JiY.LiuR.ZhuX.WangK.YangX.et al (2023)

From day 1 of one period to day 1 of the next, this cycle typically lasts ~28 days (51)

Metformin, as indirect activator of AMPK, exhibits significant anti-tumor roles in this situation by stimulating metabolic stress and increasing insulin sensitivity (181)

The mtGSH maintains mitochondrial integrity and promotes adaptive survival responses induced by prolonged cytoplasmic GSH loss, including upregulation of anti-apoptotic proteins such as BCL2 37,38